While a lot has changed in the business world over the past several decades, the fundamentals of building a strong business have not, Branson notes: "The principles are the same and still fit what I am good at: finding markets that need shaking up, coming up with ways to make people's lives better, then finding brilliant people to bring it to life.

"Once an entrepreneur, always an entrepreneur. I know I'd find a gap in the market somewhere."

- Kathleen Elkins for CNBC